Medical marijuana patients and advocates are taking their lawsuit against the Drug Enforcement Administration (DEA) all the way to the U.S. Supreme Court.

In a petition filed last month and formally docketed with the high court on Thursday, the plaintiffs asked the justices to take up their case challenging the constitutionality of federal cannabis prohibition. This comes after a series of rulings in lower courts since the original lawsuit was filed in 2017.

Lawyers representing the coalition of medical cannabis patients and activists—including Alexis Bortell and former NFL player Marvin Washington—said in April that the past rulings in the case made it clear their only source of acceptable relief would come from the Supreme Court.

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